By Neus Ferrando Gilabert BSc, MSc (embryologist).
Last Update: 05/05/2014

The follicle-stimulating hormone or FSH is a type of gonadotropic hormone secreted by the pituitary gland in men and women. In both cases, it regulates the reproductive cycle.

It is responsible for estrogen secretion and its name “follicle-stimulating” comes from the function it performs in women: it triggers follicle development and growth within the follicles in the ovary until one follicle is fully mature.

In assisted reproductive treatments, it is prescribed for ovulation induction in artificial insemination, in vitro fertilisation, or ICSI cycles with the aim of triggering follicle growth and development.

The different sections of this article have been assembled into the following table of contents.

Indications

Medicaments containing FSH as a drug for assisted reproductive treatments are indicated in the following cases:

Advantages

The advantages of using FSH in order to increase the number of eggs produced are as follows:

  • FSH, and especially recombinant FSH, has few side effects, since it is purer and contains no traces of urinary contaminants.
  • It produces several homogenous follicles containing a large number of oocytes throughout each stimulation cycle.
  • It is highly effective, since a low dose may be enough for performing a correct ovarian stimulation.

Disadvantages

The disadvantages of using FSH for assisted reproductive treatments are as follows:

  • If it is not correctly supervised by the gynecologist, the dose administered may lead to ovarian hyperstimulation syndrome (OHSS)
  • Multiple births: due to the development of more than one follicle, it may cause this type of pregnancy, especially in artificial insemination treatments.
  • High economic cost: in particular, recombinant FSH is more expensive than urinary-derived FSH

FSH medications

Depending on origin, there are two types of FSH preparation as a medication. These types are mentioned hereafter:

Urinary-derived FSH

Traditionally, this is how the largest amount of FSH is obtained. Urinary-derived FSH derives from the urine of menopausal women. Menopausal women no longer develop follicles, which mean they present high levels of FSH in their urine.

There are two types of urinary-derived FSH preparations:

  • hMG (a.k.a. menotropin): human menopausal gonadotropin, which contains 75 IU FSH and 75 IU (international units) LH. These medications are known as Menopur and hMG-lepori.
  • Highly purified urinary FSH: it contains FSH in its entirety, with only 0.1. IU LH.

Recombinant FSH

Recombinant-derived FSH is obtained by means of genetic engineering. In this case, there is only presence of FSH (no traces of LH). These drugs are Gonal and Puregon.

There is also another medicine known as Pergoveris. It is a mixture of different gonadotropins, since it has 150 IU recombinant FSH and 75 IU recombinant LH.

Sharing is caring

Our editors have made great efforts to create this content for you. By sharing this post, you are helping us to keep ourselves motivated to work even harder.

Authors and contributors

 Neus Ferrando Gilabert
BSc, MSc
Embryologist
Bachelor's Degree in Biology from the University of Valencia (UV). Postgraduate Course in Biotechnology of Human Assisted Reproduction from the Miguel Hernández University of Elche (UMH). Experience managing Embryology and Andrology Labs at Centro Médico Manzanera (Logroño, Spain). More information
Follow us on social media

Find the latest news on assisted reproduction in our channels.